Grey's Anatomy Season 22 Episode 5: Release date news, time, streaming details, cast, and more

Grey's Anatomy season 22 fans are in for an emotional rollercoaster as Season 22 continues to delve into more complex cases and relationship undercurrents. Episode 5, titled ‘Sometimes I Feel Like a Motherless Child’, is all set to air on ABC on Thursday, November 6, 2025, at 10 PM ET. The episode will be available to stream on Hulu the next day.

In the previous episode of Grey's Anatomy Season 22, we saw Meredith get into an argument with Jackson and finally decide to head back to Boston to continue her research on Alzheimer’s disease. Meanwhile, Teddy comes face-to-face with Nora, and they share a heartwarming moment about their current lives. Also, Link is discharged and eager to get back to work.

In Grey's Anatomy Season 22 Episode 5, we find Jo facing a challenging case with an expectant mother. Blue and Jules are caring for a diabetic patient that leads to some complications, and Simone learns an unexpected detail about her patient.

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Grey's Anatomy Season 22 Episode 5 release and streaming details

Grey's Anatomy Season 22 Episode 5, titled ‘Sometimes I Feel Like a Motherless Child’, will premiere on ABC on Thursday, November 6, 2025, at 10 PM ET/9 PM CT. The episode will be available on the streaming platform Hulu the following day.

To watch Grey's Anatomy Season 22 on Hulu, choose from various subscription options. The Disney+ and Hulu bundle with ads is available at $12.99 per month. The premium plan with no ads is priced at $19.99 per month.

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Grey's Anatomy Season 22 Episode 5 Cast

The beloved medical professionals of Grey Sloan Memorial Hospital will be returning for Grey's Anatomy Season 22 Episode 5. Here is a look at some of the cast members:

Chandra Wilson – Dr. Miranda Bailey

James Pickens Jr. – Dr. Richard Webber

Kevin McKidd – Owen Hunt

Camilla Luddington – Dr. Jo Wilson

Jason George – Ben Warren

Kim Raver – Dr. Teddy Altman

Chris Carmack – Dr. Atticus Lincoln

Alexis Floyd – Simone Griffin

Harry Shum Jr. – Dr. Benson “Blue” Kwan

Adelaide Kane – Dr. Jules Millin

Niko Terho – Lucas Adams

Trevor Jackson – Wes Bryant

Anita Kalathara – Dr. Kavita Mohanty

Ellen Pompeo – Dr. Meredith Grey

Anthony Hill – Dr. Winston Ndugu

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What to expect in Grey's Anatomy Season 22 Episode 5?

In the last episode of Grey's Anatomy Season 22, we saw Meredith preparing to leave the hospital to continue her research, while Jackson returned to work in plastics. Blue extended an olive branch to Mohanty when he stepped out during a surgery so she could scrub in. Link got discharged and was keen to return to work. Owen met Nora at the hospital, and the two headed out for dinner, while Teddy and Cass decided to work on their relationship.

In the upcoming episode, a heavily pregnant Jo is handling a complex case involving an expectant mother. Meanwhile, Blue and Jules face a setback while caring for their diabetic patient, and Simone makes a surprising discovery while treating her own.

As per Rotten Tomatoes, the logline for Season 22 Episode 5, titled ‘Sometimes I Feel Like a Motherless Child’, reads:

Jo navigates a challenging case with a pregnant mother; Blue and Jules care for a diabetic patient; Simone treats a patient with a surprising revelation.

Watch Grey's Anatomy Season 22 Episode 5 on ABC at 10 PM ET on November 6, 2025. The episode will also be available to stream on Hulu.

ALSO READ: Grey’s Anatomy Season 22 Episode 4 recap: Meredith and Jackson are at loggerheads

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