Grey's Anatomy Season 22 cast and character guide: Meet the new and returning actors in the ABC series 

Grey's Anatomy Season 22 features a multicultural cast of seasoned stalwarts, familiar favorites, and newcomers, all ready to weave drama at Grey Sloan Memorial Hospital.

Ellen Pompeo, Chandra Wilson, James Pickens Jr., Kevin McKidd, Camilla Luddington, Kim Raver, Caterina Scorsone, Chris Carmack, Jason George, Anthony Hill, Alexis Floyd, Harry Shum Jr., Adelaide Kane, and Niko Terho receive series regular billing this season.

Recurring cast members include Trevor Jackson, and guest episodes feature Debbie Allen (Catherine Fox), Scott Speedman (Nick Marsh), Jaicy Elliot (Taryn Helm), and Floriana Lima (Nora Young).

Grey's Anatomy Season 22 starts on October 9, 2025, and runs for 18 episodes under showrunner Meg Marinis. Ellen Pompeo, returning as Meredith Grey, is also still the narrator but appears in only a few episodes.

The original cast members, Chandra Wilson (Miranda Bailey) and James Pickens Jr. (Richard Webber) have been present since the beginning. They helped bridge continuity to the hospital that is tackling new and ongoing challenges.

---

Main cast of Grey's Anatomy Season 22

Ellen Pompeo as Dr. Meredith Grey

Pompeo guest stars in Season 22 and appears in around seven episodes, narrating the show. She ties together past and new plotlines.

Chandra Wilson as Dr. Miranda Bailey

Bailey shows up in Season 22 of Grey's Anatomy, oscillating between administrative work and surgical duties.

James Pickens Jr. as Dr. Richard Webber

Webber is the most senior Grey Sloan character in all the episodes this season.

Kevin McKidd as Dr. Owen Hunt

Owen remains a core member of the trauma surgery team, providing leadership throughout the entire season.

Caterina Scorsone as Dr. Amelia Shepherd

Amelia returns as a recurring cast member, possibly with a variable episode count due to juggling Grey's Anatomy Season 22 and Station 19 guest appearances. She remains a neurosurgeon with complicated personal and professional relationships.

Camilla Luddington as Dr. Jo Wilson

Jo returns to OB/GYN and continues to navigate patient care, her personal life, and hospital politics.

Kim Raver as Dr. Teddy Altman

Teddy continues to work in surgical support and hospital operations in a leadership role.

Chris Carmack as Dr. Atticus "Link" Lincoln

Link, who survived Season 21's explosion, still remains an orthopedic surgeon in Grey's Anatomy Season 22, focusing on personal healing and professional healing.

Jason George as Dr. Ben Warren

Ben stays at Grey Sloan after transferring from Station 19, linking storylines between the two shows.

Anthony Hill as Dr. Winston Ndugu

Winston is upgraded from recurring to more prominent appearances on Grey's Anatomy Season 22, bringing new energy to the main cast.

Alexis Floyd as Dr. Simone Griffith

Simone is a resident navigating challenging cases and workplace dynamics.

Harry Shum Jr. as Dr. Benson “Blue” Kwan

Blue is one of the younger residents, involved in hospital politics and rivalries.

Adelaide Kane as Dr. Jules Millin

Jules continues on the surgical staff with professional and personal agendas in play.

Niko Terho as Dr. Lucas Adams

Lucas remains a resident, closely connected to hospital life and Meredith Grey's legacy..

---

Grey's Anatomy Season 22 exits and goodbyes

Jake Borelli (Dr. Levi Schmitt) and Midori Francis (Dr. Mika Yasuda) exit as series regulars, along with adjustments from Season 21's storyline. Some new cast members, such as Anthony Hill, are upgraded to series regulars but may still appear in recurring storylines. Other major or recurring castings may be revealed closer to or during the season premiere.

---

Grey's Anatomy Season 22 recurring and guest cast

Debbie Allen as Dr. Catherine Fox reprises her recurring role, bringing family baggage and authority at Grey Sloan.

Scott Speedman as Dr. Nick Marsh continues his guest role.

Jaicy Elliot as Dr. Taryn Helm and Floriana Lima as Nora Young recur in ongoing storylines.

Trevor Jackson joins as a recurring cast member.

Guest stars Jade Pettyjohn and Curtis Edward Jackson appear in short story arcs.

---

Behind the scenes: production information

Grey's Anatomy Season 22 has already been ordered by showrunner Meg Marinis. Ellen Pompeo appears through narration and selective guest spots, with Chandra Wilson and James Pickens Jr. featuring in every episode.

Season 22 premieres on October 9, 2025, continuing the blend of medical drama with professional and personal storylines.

---

Grey's Anatomy Season 22 maintains continuity of the original cast while rejuvenating newer additions and returnees. Having lost stalwarts Jake Borelli and Midori Francis and added Trevor Jackson, the cast is renewed, but the core theme of life at Grey Sloan Memorial remains.

The season will once again feature increased surgery cases, hospital politics, and character-driven storylines.

Also read: Grey's Anatomy Season 22: Release date news, cast details, streaming details and more about the upcoming chapter of the medical drama